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Explore Dentulu’s comprehensive library of peer-reviewed, evidence-based research papers that explain how oral health impacts systemic disease. Written for clinicians, researchers, and patients seeking clarity and science-backed insights.
Complete Research Database
Comprehensive oral-systemic research organized by medical specialty. Each connection includes peer-reviewed evidence, clinical implications, and screening protocols.
Porphyromonas gingivalis triggers Rheumatoid Arthritis
Bacterial citrullination from P. gingivalis activates immune responses linked to joint inflammation.
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Oral Pathogens as Alzheimer’s Markers
Gingipain toxins from P. gingivalis can enter the brain and accelerate neurodegenerative damage.
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Periodontitis & Systemic Inflammation
Gum inflammation raises systemic CRP and IL-6 levels, driving whole-body inflammatory stress.
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The Oral–Heart Disease Connection
Oral bacteria entering the bloodstream can contribute to arterial plaque formation.
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Salivary Microbiome as a Metabolic Marker
Salivary microbial patterns help predict metabolic risks like obesity, insulin resistance, and hypertension.
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Periodontitis and Diabetes: The Two-Way Link
Gum disease worsens glucose control, while treatment improves HbA1c and reduces inflammation.
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Treating Gum Disease to Prevent Preterm Birth
Maternal gum infection increases inflammatory risk factors associated with preterm delivery.
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Mouth Bacteria as a Source of Pneumonia
Oral bacteria aspirated into the lungs can trigger respiratory infections and pneumonia.
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The Gum–Lung Connection in COPD
Poor oral health increases airway inflammation and worsens COPD flare-ups.
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Gum Disease and Stroke Risk
Chronic gum inflammation contributes to vascular damage and higher stroke risk.
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